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AIF-M1 Monoclonal Antibody

商品貨號： PLA004624

適應性： 人,小鼠,大鼠,猴

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： AIFM1
蛋白名稱： Apoptosis-inducing factor 1 mitochondrial
Human_gene_id： 9131
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9131
Human_swiss_prot_no： O95831
Human_swiss_link： http://www.uniprot.org/uniprotkb/O95831/entry
Mouse_gene_id： 26926
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26926
Mouse_swiss_prot_no： Q9Z0X1
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9Z0X1
Rat_gene_id： 83533
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83533
Rat_swiss_prot_no： Q9JM53
Rat_swiss_link： http://www.uniprot.org/uniprot/Q9JM53
特異性： AIF-M1 Monoclonal Antibody detects endogenous levels of AIF-M1 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： AIFM1; AIF; PDCD8; Apoptosis-inducing factor 1; mitochondrial; Programmed cell death protein 8
信號通路： Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;
功能： catalytic activity:2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol.,cofactor:FAD.,function:Possesses significant protein thiol-disulfide oxidase activity.,function:Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Extramitochondrial AIF induces nuclear chromatin condensation and large scale DNA fragmentation (in vitro). Binds to DNA in a sequence-independent manner.,similarity:Belongs to the FAD-dependent oxidoreductase family.,similarity:Contains 1 thioredoxin domain.,subcellular location:Translocated to the nucleus upon induction of apoptosis.,subunit:Interacts with XIAP.,tissue specificity:Widely expressed.,
相關產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Mitochondrion intermembrane space . Mitochondrion inner membrane. Cytoplasm . Nucleus . Cytoplasm, perinuclear region . Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis (PubMed:15775970). Colocalizes with EIF3G in the nucleus and perinuclear region (PubMed:17094969). .; [Isoform 3]: Mitochondrion intermembrane space . Mitochondrion inner membrane . Has a stronger membrane anchorage than isoform 1. .; [Isoform 4]: Mitochondrion . Cytoplasm, cytosol . In pro-apoptotic conditions, is released from mitochondria to cytosol in a calpain/cathepsin-dependent manner. .; [Isoform 5]: Cytoplasm .
組織表達： Expressed in all tested tissues (PubMed:16644725). Detected in muscle and skin fibroblasts (at protein level) (PubMed:23217327). Expressed in osteoblasts (at protein level) (PubMed:28842795). ; [Isoform 3]: Brain specific. ; [Isoform 4]: Expressed in all tested tissues except brain. ; [Isoform 5]: Isoform 5 is frequently down-regulated in human cancers.
科研貨號： PLA004624

AIF-M1 Monoclonal Antibody

Catalog No PLA004624

Product information

發(fā)貨日期： 7
基因名稱： AIFM1
蛋白名稱： Apoptosis-inducing factor 1 mitochondrial
Human_gene_id： 9131
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9131
Human_swiss_prot_no： O95831
Human_swiss_link： http://www.uniprot.org/uniprotkb/O95831/entry
Mouse_gene_id： 26926
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26926
Mouse_swiss_prot_no： Q9Z0X1
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9Z0X1
Rat_gene_id： 83533
Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83533
Rat_swiss_prot_no： Q9JM53
Rat_swiss_link： http://www.uniprot.org/uniprot/Q9JM53
特異性： AIF-M1 Monoclonal Antibody detects endogenous levels of AIF-M1 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： AIFM1; AIF; PDCD8; Apoptosis-inducing factor 1; mitochondrial; Programmed cell death protein 8
信號通路： Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;
功能： catalytic activity:2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol.,cofactor:FAD.,function:Possesses significant protein thiol-disulfide oxidase activity.,function:Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Extramitochondrial AIF induces nuclear chromatin condensation and large scale DNA fragmentation (in vitro). Binds to DNA in a sequence-independent manner.,similarity:Belongs to the FAD-dependent oxidoreductase family.,similarity:Contains 1 thioredoxin domain.,subcellular location:Translocated to the nucleus upon induction of apoptosis.,subunit:Interacts with XIAP.,tissue specificity:Widely expressed.,
相關產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Mitochondrion intermembrane space . Mitochondrion inner membrane. Cytoplasm . Nucleus . Cytoplasm, perinuclear region . Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis (PubMed:15775970). Colocalizes with EIF3G in the nucleus and perinuclear region (PubMed:17094969). .; [Isoform 3]: Mitochondrion intermembrane space . Mitochondrion inner membrane . Has a stronger membrane anchorage than isoform 1. .; [Isoform 4]: Mitochondrion . Cytoplasm, cytosol . In pro-apoptotic conditions, is released from mitochondria to cytosol in a calpain/cathepsin-dependent manner. .; [Isoform 5]: Cytoplasm .
組織表達： Expressed in all tested tissues (PubMed:16644725). Detected in muscle and skin fibroblasts (at protein level) (PubMed:23217327). Expressed in osteoblasts (at protein level) (PubMed:28842795). ; [Isoform 3]: Brain specific. ; [Isoform 4]: Expressed in all tested tissues except brain. ; [Isoform 5]: Isoform 5 is frequently down-regulated in human cancers.
科研貨號： PLA004624

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