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4E-BP1 Monoclonal Antibody

商品貨號： PLA004616

適應(yīng) 性： 人

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

發(fā)貨日期： 7
基因名稱： EIF4EBP1
蛋白名稱： Eukaryotic translation initiation factor 4E-binding protein 1
Human_gene_id： 1978
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1978
Human_swiss_prot_no： Q13541
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q13541/entry
Mouse_swiss_prot_no： Q60876
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q60876
特異性： 4E-BP1 Monoclonal Antibody detects endogenous levels of 4E-BP1 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I
信號通路： Regulates Angiogenesis; Insulin Receptor; mTOR; ErbB/HER; PI3K/Akt; AMPK
功能： function:Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway.,PTM:Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the eIF4E-binding protein family.,subunit:Nonphosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Rapamycin can attenuate insulin stimulation, mediated by FKBPs.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： nucleoplasm,cytoplasm,cytosol,protein complex,
組織表達(dá)： Colon,Epithelium,Lung,Placenta,Platelet,
科研貨號： PLA004616

4E-BP1 Monoclonal Antibody

Catalog No PLA004616

Product information

發(fā)貨日期： 7
基因名稱： EIF4EBP1
蛋白名稱： Eukaryotic translation initiation factor 4E-binding protein 1
Human_gene_id： 1978
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1978
Human_swiss_prot_no： Q13541
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q13541/entry
Mouse_swiss_prot_no： Q60876
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q60876
特異性： 4E-BP1 Monoclonal Antibody detects endogenous levels of 4E-BP1 protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Monoclonal, Mouse
稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
純化工藝： Affinity purification
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I
信號通路： Regulates Angiogenesis; Insulin Receptor; mTOR; ErbB/HER; PI3K/Akt; AMPK
功能： function:Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway.,PTM:Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the eIF4E-binding protein family.,subunit:Nonphosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Rapamycin can attenuate insulin stimulation, mediated by FKBPs.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： nucleoplasm,cytoplasm,cytosol,protein complex,
組織表達(dá)： Colon,Epithelium,Lung,Placenta,Platelet,
科研貨號： PLA004616

Hunan UPT Biotechnology Co.,Ltd

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