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NOTCH4 (Cleaved-Val1467) rabbit pAb

商品貨號(hào)： PLA004477

適應(yīng) 性： 人,猴

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說(shuō)明書(shū)

商品描述

基因名稱： NOTCH4 INT3
蛋白名稱： NOTCH4 (Cleaved-Val1467)
Human_gene_id： 4855
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4855
Human_swiss_prot_no： Q99466
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q99466/entry
Mouse_gene_id： 18132
Mouse_gene_link： https://www.uniprot.org/uniprot/18132
Mouse_swiss_prot_no： P31695
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P31695
特異性： This antibody detects endogenous levels of Human,Monkey NOTCH4 (Cleaved-Val1467, protein was cleaved amino acid sequence between 1466-1467 )
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Polyclonal, Rabbit,IgG
稀釋： WB 1:1000-2000 ELISA 1:5000-20000
純化工藝： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱： Neurogenic locus notch homolog protein 4 (Notch 4;hNotch4) [Cleaved into: Notch 4 extracellular truncation; Notch 4 intracellular domain]
實(shí)測(cè)條帶： 60 220kD
功能： alternative products:Experimental confirmation may be lacking for some isoforms,function:Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system.,polymorphism:The poly-Leu region of NOTCH4 (in the signal peptide) is polymorphic and the number of Leu varies in the population (from 6 to 12).,PTM:Phosphorylated.,PTM:Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane.,similarity:Belongs to the NOTCH family.,similarity:Contains 28 EGF-like domains.,similarity:Contains 3 LNR (Lin/Notch) repeats.,similarity:Contains 5 ANK repeats.,subcellular location:Following proteolytical processing NICD is translocated to the nucleus.,subunit:Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds (By similarity). Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH4.,tissue specificity:Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3124
細(xì)胞定位： Cell membrane; Single-pass type I membrane protein.; [Notch 4 intracellular domain]: Nucleus. Following proteolytical processing NICD is translocated to the nucleus.
組織表達(dá)： Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.
科研貨號(hào)： PLA004477

NOTCH4 (Cleaved-Val1467) rabbit pAb

Catalog No PLA004477

Product information

基因名稱： NOTCH4 INT3
蛋白名稱： NOTCH4 (Cleaved-Val1467)
Human_gene_id： 4855
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4855
Human_swiss_prot_no： Q99466
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q99466/entry
Mouse_gene_id： 18132
Mouse_gene_link： https://www.uniprot.org/uniprot/18132
Mouse_swiss_prot_no： P31695
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P31695
特異性： This antibody detects endogenous levels of Human,Monkey NOTCH4 (Cleaved-Val1467, protein was cleaved amino acid sequence between 1466-1467 )
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Polyclonal, Rabbit,IgG
稀釋： WB 1:1000-2000 ELISA 1:5000-20000
純化工藝： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱： Neurogenic locus notch homolog protein 4 (Notch 4;hNotch4) [Cleaved into: Notch 4 extracellular truncation; Notch 4 intracellular domain]
實(shí)測(cè)條帶： 60 220kD
功能： alternative products:Experimental confirmation may be lacking for some isoforms,function:Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system.,polymorphism:The poly-Leu region of NOTCH4 (in the signal peptide) is polymorphic and the number of Leu varies in the population (from 6 to 12).,PTM:Phosphorylated.,PTM:Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane.,similarity:Belongs to the NOTCH family.,similarity:Contains 28 EGF-like domains.,similarity:Contains 3 LNR (Lin/Notch) repeats.,similarity:Contains 5 ANK repeats.,subcellular location:Following proteolytical processing NICD is translocated to the nucleus.,subunit:Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds (By similarity). Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH4.,tissue specificity:Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3124
細(xì)胞定位： Cell membrane; Single-pass type I membrane protein.; [Notch 4 intracellular domain]: Nucleus. Following proteolytical processing NICD is translocated to the nucleus.
組織表達(dá)： Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.
科研貨號(hào)： PLA004477

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