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FA9 (light chain, Cleaved-Tyr47) rabbit pAb

商品貨號： PLA004400

適應(yīng) 性： 人,小鼠,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

基因名稱： F9 Factor IX
蛋白名稱： FA9 (light chain, Cleaved-Tyr47)
Human_gene_id： 2158
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2158
Human_swiss_prot_no： P00740
Human_swiss_link： https://www.uniprot.org/uniprotkb/P00740/entry
Mouse_gene_id： 14071
Mouse_gene_link： https://www.uniprot.org/uniprot/14071
Mouse_swiss_prot_no： P16294
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P16294
Rat_gene_id： 24946
Rat_gene_link： https://www.uniprot.org/uniprot/24946
Rat_swiss_prot_no： P16296
Rat_swiss_link： https://www.uniprot.org/uniprotkb/P16296
特異性： This antibody detects endogenous levels of Human,Mouse,Rat FA9 (light chain, Cleaved-Tyr47, protein was cleaved amino acid sequence between 46-47 )
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:1000-2000 ELISA 1:5000-20000
純化工藝： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： Coagulation factor IX (EC 3.4.21.22;Christmas factor;Plasma thromboplastin component;PTC) [Cleaved into: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain]
實測條帶： 16 45kD
功能： catalytic activity:Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.,disease:Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB) [MIM:306900]; also known as Christmas disease.,disease:Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide.,domain:Calcium binds to the gamma-carboxyglutamic acid (Gla) residues and, with stronger affinity, to another site, beyond the Gla domain.,function:Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.,miscellaneous:In 1952, one of the earliest researchers of the disease, Dr. R.G. Macfarlane used the patient's surname, Christmas, to refer to the disease and also to refer to the clotting factor which he called the 'Christmas Factor' At the time Stephen Christmas was a 5-year-old boy. He died in 1993 at the age of 46 from acquired immunodeficiency syndrome contracted through treatment with blood products.,online information:Clinical information on BeneFix,online information:Factor IX entry,online information:Hemophilia B mutation database,online information:The Christmas Factor -Issue 41 of December 2003,pharmaceutical:Available under the names BeneFix (Baxter and American Home Products). Used to treat hemophilia B.,PTM:Activated by factor XIa, which excises the activation peptide.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 Gla (gamma-carboxy-glutamate) domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 EGF-like domains.,subunit:Heterodimer of a light chain and a heavy chain; disulfide-linked.,tissue specificity:Synthesized primarily in the liver and secreted in plasma.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3047
細(xì)胞定位： Secreted .
組織表達(dá)： Detected in blood plasma (at protein level) (PubMed:3857619, PubMed:8295821, PubMed:2592373, PubMed:9169594, PubMed:19846852). Synthesized primarily in the liver and secreted in plasma.
科研貨號： PLA004400

FA9 (light chain, Cleaved-Tyr47) rabbit pAb

Catalog No PLA004400

Product information

基因名稱： F9 Factor IX
蛋白名稱： FA9 (light chain, Cleaved-Tyr47)
Human_gene_id： 2158
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2158
Human_swiss_prot_no： P00740
Human_swiss_link： https://www.uniprot.org/uniprotkb/P00740/entry
Mouse_gene_id： 14071
Mouse_gene_link： https://www.uniprot.org/uniprot/14071
Mouse_swiss_prot_no： P16294
Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P16294
Rat_gene_id： 24946
Rat_gene_link： https://www.uniprot.org/uniprot/24946
Rat_swiss_prot_no： P16296
Rat_swiss_link： https://www.uniprot.org/uniprotkb/P16296
特異性： This antibody detects endogenous levels of Human,Mouse,Rat FA9 (light chain, Cleaved-Tyr47, protein was cleaved amino acid sequence between 46-47 )
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:1000-2000 ELISA 1:5000-20000
純化工藝： The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： Coagulation factor IX (EC 3.4.21.22;Christmas factor;Plasma thromboplastin component;PTC) [Cleaved into: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain]
實測條帶： 16 45kD
功能： catalytic activity:Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.,disease:Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB) [MIM:306900]; also known as Christmas disease.,disease:Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide.,domain:Calcium binds to the gamma-carboxyglutamic acid (Gla) residues and, with stronger affinity, to another site, beyond the Gla domain.,function:Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.,miscellaneous:In 1952, one of the earliest researchers of the disease, Dr. R.G. Macfarlane used the patient's surname, Christmas, to refer to the disease and also to refer to the clotting factor which he called the 'Christmas Factor' At the time Stephen Christmas was a 5-year-old boy. He died in 1993 at the age of 46 from acquired immunodeficiency syndrome contracted through treatment with blood products.,online information:Clinical information on BeneFix,online information:Factor IX entry,online information:Hemophilia B mutation database,online information:The Christmas Factor -Issue 41 of December 2003,pharmaceutical:Available under the names BeneFix (Baxter and American Home Products). Used to treat hemophilia B.,PTM:Activated by factor XIa, which excises the activation peptide.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 Gla (gamma-carboxy-glutamate) domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 EGF-like domains.,subunit:Heterodimer of a light chain and a heavy chain; disulfide-linked.,tissue specificity:Synthesized primarily in the liver and secreted in plasma.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3047
細(xì)胞定位： Secreted .
組織表達(dá)： Detected in blood plasma (at protein level) (PubMed:3857619, PubMed:8295821, PubMed:2592373, PubMed:9169594, PubMed:19846852). Synthesized primarily in the liver and secreted in plasma.
科研貨號： PLA004400

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