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Caspase 10 (p23/17, Cleaved-Val220) Antibody

商品貨號： PLA004381

適應(yīng) 性： 人,小鼠,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

基因名稱： CASP10 MCH4
蛋白名稱： Caspase10
Human_gene_id： 843
Human_swiss_prot_no： Q92851
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q92851/entry
特異性： This antibody detects endogenous levels of human Caspase 10 (p23/17, Cleaved-Val220)
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000, ELISA(peptide)1:5000-20000
純化工藝： The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： Caspase-10 (CASP-10;EC 3.4.22.63;Apoptotic protease Mch-4;FAS-associated death domain protein interleukin-1B-converting enzyme 2;FLICE2;ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]
實測條帶： 58+23kD
功能： catalytic activity:Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp-|-Gly.,disease:Defects in CASP10 are a cause of familial non-Hodgkin lymphoma (NHL) [MIM:605027]. NHL is a cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss.,disease:Defects in CASP10 are a cause of gastric cancers [MIM:137215].,disease:Defects in CASP10 are the cause of autoimmune lymphoproliferative syndrome type 2A (ALPS2A) [MIM:603909]. ALPS2 is characterized by abnormal lymphocyte and dendritic cell homeostasis and immune regulatory defects.,function:Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.,function:Isoform C is proteolytically inactive.,online information:CASP10 mutation db,online information:Caspase-10 mutations causing ALPS type II,PTM:Cleavage by granzyme B and autocatalytic activity generate the two active subunits.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the peptidase C14A family.,similarity:Contains 2 DED (death effector) domains.,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 23/17 kDa (p23/17) (depending on the splicing events) and a 12 kDa (p12) subunit (By similarity). Self-associates. Interacts with FADD and CASP8. Found in a Fas signaling complex consisting of FAS, FADD, CASP8 and CASP10.,tissue specificity:Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： cytosol,CD95 death-inducing signaling complex,ripoptosome,
組織表達： Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.
tag： hot
科研貨號： PLA004381

Caspase 10 (p23/17, Cleaved-Val220) Antibody

Catalog No PLA004381

Product information

基因名稱： CASP10 MCH4
蛋白名稱： Caspase10
Human_gene_id： 843
Human_swiss_prot_no： Q92851
Human_swiss_link： https://www.uniprot.org/uniprotkb/Q92851/entry
特異性： This antibody detects endogenous levels of human Caspase 10 (p23/17, Cleaved-Val220)
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500-2000, ELISA(peptide)1:5000-20000
純化工藝： The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： Caspase-10 (CASP-10;EC 3.4.22.63;Apoptotic protease Mch-4;FAS-associated death domain protein interleukin-1B-converting enzyme 2;FLICE2;ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]
實測條帶： 58+23kD
功能： catalytic activity:Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp-|-Gly.,disease:Defects in CASP10 are a cause of familial non-Hodgkin lymphoma (NHL) [MIM:605027]. NHL is a cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss.,disease:Defects in CASP10 are a cause of gastric cancers [MIM:137215].,disease:Defects in CASP10 are the cause of autoimmune lymphoproliferative syndrome type 2A (ALPS2A) [MIM:603909]. ALPS2 is characterized by abnormal lymphocyte and dendritic cell homeostasis and immune regulatory defects.,function:Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.,function:Isoform C is proteolytically inactive.,online information:CASP10 mutation db,online information:Caspase-10 mutations causing ALPS type II,PTM:Cleavage by granzyme B and autocatalytic activity generate the two active subunits.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the peptidase C14A family.,similarity:Contains 2 DED (death effector) domains.,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 23/17 kDa (p23/17) (depending on the splicing events) and a 12 kDa (p12) subunit (By similarity). Self-associates. Interacts with FADD and CASP8. Found in a Fas signaling complex consisting of FAS, FADD, CASP8 and CASP10.,tissue specificity:Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： cytosol,CD95 death-inducing signaling complex,ripoptosome,
組織表達： Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.
tag： hot
科研貨號： PLA004381

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