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Cleaved-C1r LC (I464) Polyclonal Antibody

商品貨號： PLA004298

適應(yīng) 性： 人,大鼠,小鼠,

￥600元

規(guī)格：

40μL 100μL 200μL

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MSDS

說明書

商品描述

基因名稱： C1R
蛋白名稱： Complement C1r subcomponent
Human_gene_id： 715
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=715
Human_swiss_prot_no： P00736
Human_swiss_link： http://www.uniprot.org/uniprotkb/P00736/entry
特異性： Cleaved-C1r LC (I464) Polyclonal Antibody detects endogenous levels of fragment of activated C1r LC protein resulting from cleavage adjacent to I464.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： C1R; Complement C1r subcomponent; Complement component 1 subcomponent r
實測條帶： 27kD
信號通路： Complement and coagulation cascades;Systemic lupus erythematosus;
功能： catalytic activity:Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3.4.21.42).,function:C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.,polymorphism:Complement component C1r deficiency [MIM:216950] leads to the failure of the classical complement system activation pathway (C1 deficiency). Individuals with C1 deficiency are highly susceptible to infections by microorganisms and have greater risk in developing autoimmune diseases such as systemic lupus erythematosus (SLE).,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, A and B, connected by disulfide bonds.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Secreted .
組織表達： Adipose tissue,Colon endothelium,Liver,Plasma,Skin,
科研貨號： PLA004298

Cleaved-C1r LC (I464) Polyclonal Antibody

Catalog No PLA004298

Product information

基因名稱： C1R
蛋白名稱： Complement C1r subcomponent
Human_gene_id： 715
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=715
Human_swiss_prot_no： P00736
Human_swiss_link： http://www.uniprot.org/uniprotkb/P00736/entry
特異性： Cleaved-C1r LC (I464) Polyclonal Antibody detects endogenous levels of fragment of activated C1r LC protein resulting from cleavage adjacent to I464.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來源： Polyclonal, Rabbit,IgG
稀釋： WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
說明書： 1
Msds： MSDS_Antibody.pdf
其他名稱： C1R; Complement C1r subcomponent; Complement component 1 subcomponent r
實測條帶： 27kD
信號通路： Complement and coagulation cascades;Systemic lupus erythematosus;
功能： catalytic activity:Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3.4.21.42).,function:C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.,polymorphism:Complement component C1r deficiency [MIM:216950] leads to the failure of the classical complement system activation pathway (C1 deficiency). Individuals with C1 deficiency are highly susceptible to infections by microorganisms and have greater risk in developing autoimmune diseases such as systemic lupus erythematosus (SLE).,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, A and B, connected by disulfide bonds.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細胞定位： Secreted .
組織表達： Adipose tissue,Colon endothelium,Liver,Plasma,Skin,
科研貨號： PLA004298

Hunan UPT Biotechnology Co.,Ltd

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