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首頁 > 抗體 > 一抗 > 其它 > Cleaved-C1r HC (R463) Polyclonal Antibody
Cleaved-C1r HC (R463) Polyclonal Antibody
商品貨號: PLA004297
適 應(yīng) 性: 人,大鼠,小鼠,
WB ELISA
¥600元
規(guī)格:
在線咨詢
MSDS
說明書
商品描述
  • 基因名稱: C1R
  • 蛋白名稱: Complement C1r subcomponent
  • Human_gene_id: 715
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=715
  • Human_swiss_prot_no: P00736
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P00736/entry
  • 特異性: Cleaved-C1r HC (R463) Polyclonal Antibody detects endogenous levels of fragment of activated C1r HC protein resulting from cleavage adjacent to R463.
  • 組成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源: Polyclonal, Rabbit,IgG
  • 稀釋: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
  • 純化工藝: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度: 1 mg/ml
  • 儲存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名稱: C1R; Complement C1r subcomponent; Complement component 1 subcomponent r
  • 實測條帶: 51kD
  • 信號通路: Complement and coagulation cascades;Systemic lupus erythematosus;
  • 功能: catalytic activity:Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3.4.21.42).,function:C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.,polymorphism:Complement component C1r deficiency [MIM:216950] leads to the failure of the classical complement system activation pathway (C1 deficiency). Individuals with C1 deficiency are highly susceptible to infections by microorganisms and have greater risk in developing autoimmune diseases such as systemic lupus erythematosus (SLE).,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, A and B, connected by disulfide bonds.,
  • 相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位: Secreted .
  • 組織表達(dá): Adipose tissue,Colon endothelium,Liver,Plasma,Skin,
  • 科研貨號: PLA004297
Cleaved-C1r HC (R463) Polyclonal Antibody
Catalog No PLA004297
Product information
  • 基因名稱: C1R
  • 蛋白名稱: Complement C1r subcomponent
  • Human_gene_id: 715
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=715
  • Human_swiss_prot_no: P00736
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P00736/entry
  • 特異性: Cleaved-C1r HC (R463) Polyclonal Antibody detects endogenous levels of fragment of activated C1r HC protein resulting from cleavage adjacent to R463.
  • 組成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源: Polyclonal, Rabbit,IgG
  • 稀釋: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
  • 純化工藝: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度: 1 mg/ml
  • 儲存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名稱: C1R; Complement C1r subcomponent; Complement component 1 subcomponent r
  • 實測條帶: 51kD
  • 信號通路: Complement and coagulation cascades;Systemic lupus erythematosus;
  • 功能: catalytic activity:Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3.4.21.42).,function:C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.,polymorphism:Complement component C1r deficiency [MIM:216950] leads to the failure of the classical complement system activation pathway (C1 deficiency). Individuals with C1 deficiency are highly susceptible to infections by microorganisms and have greater risk in developing autoimmune diseases such as systemic lupus erythematosus (SLE).,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, A and B, connected by disulfide bonds.,
  • 相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位: Secreted .
  • 組織表達(dá): Adipose tissue,Colon endothelium,Liver,Plasma,Skin,
  • 科研貨號: PLA004297
  • Hunan UPT Biotechnology Co.,Ltd
    Website:m.hyjdss.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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