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Total Ref-1 Cell-Based Colorimetric ELISA Kit

商品貨號： PLA001370

適應(yīng) 性： 人,小鼠,大鼠

￥2400元

規(guī)格：

96T

在線咨詢

MSDS

說明書

商品描述

發(fā)貨日期： 14
基因名稱： APEX1
Human_gene_id： 328
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=328
Human_swiss_prot_no： P27695
Human_swiss_link： http://www.uniprot.org/uniprotkb/P27695/entry
Mouse_swiss_prot_no： P28352
Mouse_swiss_link： http://www.uniprot.org/uniprot/P28352
Rat_swiss_prot_no： P43138
Rat_swiss_link： http://www.uniprot.org/uniprot/O54941P43138
儲存： 2-8°C/6 months
說明書： KA3575C.pdf
其他名稱： DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (REF-1) (Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial]
功能： DNA metabolic process,?DNA repair,?base-excision repair,?transcription,?transcription, DNA-dependent,?transcription from RNA polymerase II promoter,?response to DNA damage stimulus,?cellular homeostasis,?RNA biosynthetic process,cellular response to stress,?homeostatic process,?cell redox homeostasis,?regulation of binding,?regulation of DNA binding,
相關(guān)產(chǎn)品： YT5321,YT4039,YK0023,YK0022,KA3575C
細(xì)胞定位： Nucleus. Nucleus, nucleolus. Nucleus speckle. Endoplasmic reticulum. Cytoplasm. Detected in the cytoplasm of B-cells stimulated to switch (By similarity). Colocalized with SIRT1 in the nucleus. Colocalized with YBX1 in nuclear speckles after genotoxic stress. Together with OGG1 is recruited to nuclear speckles in UVA-irradiated cells. Colocalized with nucleolin and NPM1 in the nucleolus. Its nucleolar localization is cell cycle dependent and requires active rRNA transcription. Colocalized with calreticulin in the endoplasmic reticulum. Translocation from the nucleus to the cytoplasm is stimulated in presence of nitric oxide (NO) and function in a CRM1-dependent manner, possibly as a consequence of demasking a nuclear export signal (amino acid position 64-80). S-nitrosylation at Cys-93 and Cys-310 regulates its nuclear-cytosolic shuttling. Ubiquitinated form is localized predominantly in the cytoplasm. .; [DNA-(apurinic or apyrimidinic site) endonuclease, mitochondrial]: Mitochondrion. The cleaved APEX2 is only detected in mitochondria (By similarity). Translocation from the cytoplasm to the mitochondria is mediated by ROS signaling and cleavage mediated by granzyme A. Tom20-dependent translocated mitochondrial APEX1 level is significantly increased after genotoxic stress. .
科研貨號： PLA001370

Total Ref-1 Cell-Based Colorimetric ELISA Kit

Catalog No PLA001370

Product information

發(fā)貨日期： 14
基因名稱： APEX1
Human_gene_id： 328
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=328
Human_swiss_prot_no： P27695
Human_swiss_link： http://www.uniprot.org/uniprotkb/P27695/entry
Mouse_swiss_prot_no： P28352
Mouse_swiss_link： http://www.uniprot.org/uniprot/P28352
Rat_swiss_prot_no： P43138
Rat_swiss_link： http://www.uniprot.org/uniprot/O54941P43138
儲存： 2-8°C/6 months
說明書： KA3575C.pdf
其他名稱： DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (REF-1) (Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial]
功能： DNA metabolic process,?DNA repair,?base-excision repair,?transcription,?transcription, DNA-dependent,?transcription from RNA polymerase II promoter,?response to DNA damage stimulus,?cellular homeostasis,?RNA biosynthetic process,cellular response to stress,?homeostatic process,?cell redox homeostasis,?regulation of binding,?regulation of DNA binding,
相關(guān)產(chǎn)品： YT5321,YT4039,YK0023,YK0022,KA3575C
細(xì)胞定位： Nucleus. Nucleus, nucleolus. Nucleus speckle. Endoplasmic reticulum. Cytoplasm. Detected in the cytoplasm of B-cells stimulated to switch (By similarity). Colocalized with SIRT1 in the nucleus. Colocalized with YBX1 in nuclear speckles after genotoxic stress. Together with OGG1 is recruited to nuclear speckles in UVA-irradiated cells. Colocalized with nucleolin and NPM1 in the nucleolus. Its nucleolar localization is cell cycle dependent and requires active rRNA transcription. Colocalized with calreticulin in the endoplasmic reticulum. Translocation from the nucleus to the cytoplasm is stimulated in presence of nitric oxide (NO) and function in a CRM1-dependent manner, possibly as a consequence of demasking a nuclear export signal (amino acid position 64-80). S-nitrosylation at Cys-93 and Cys-310 regulates its nuclear-cytosolic shuttling. Ubiquitinated form is localized predominantly in the cytoplasm. .; [DNA-(apurinic or apyrimidinic site) endonuclease, mitochondrial]: Mitochondrion. The cleaved APEX2 is only detected in mitochondria (By similarity). Translocation from the cytoplasm to the mitochondria is mediated by ROS signaling and cleavage mediated by granzyme A. Tom20-dependent translocated mitochondrial APEX1 level is significantly increased after genotoxic stress. .
科研貨號： PLA001370

Hunan UPT Biotechnology Co.,Ltd

Website：m.hyjdss.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.

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