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Total Seprase Cell-Based Colorimetric ELISA Kit

商品貨號(hào)： PLA001050

適應(yīng) 性： 人,小鼠,大鼠

￥2400元

規(guī)格：

96T

在線咨詢

MSDS

說(shuō)明書

商品描述

發(fā)貨日期： 14
基因名稱： FAP
Human_gene_id： 2191
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2191
Human_swiss_prot_no： Q12884
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q12884/entry
Mouse_swiss_prot_no： P97321
Mouse_swiss_link： http://www.uniprot.org/uniprot/P97321
儲(chǔ)存： 2-8°C/6 months
說(shuō)明書： KA3255C.pdf
其他名稱： Seprase (EC 3.4.21.-) (170 kDa melanoma membrane-bound gelatinase) (Fibroblast activation protein alpha) (Integral membrane serine protease)
功能： proteolysis,
相關(guān)產(chǎn)品： YT6136,YT4244,KA3255C,KE1372,KE1709
細(xì)胞定位： [Prolyl endopeptidase FAP]: Cell surface . Cell membrane ; Single-pass type II membrane protein . Cell projection, lamellipodium membrane ; Single-pass type II membrane protein . Cell projection, invadopodium membrane ; Single-pass type II membrane protein . Cell projection, ruffle membrane ; Single-pass type II membrane protein . Membrane ; Single-pass type II membrane protein . Localized on cell surface with lamellipodia and invadopodia membranes and on shed vesicles. Colocalized with DPP4 at invadopodia and lamellipodia membranes of migratory activated endothelial cells in collagenous matrix. Colocalized with DPP4 on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. Anchored and enriched preferentially by integrin alpha-3/beta-1 at invadopodia, plasma membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner. Colocalized with PLAUR preferentially at the cell surface of invadopodia membranes in a cytoskeleton-, integrin- and vitronectin-dependent manner. Concentrated at invadopodia membranes, specialized protrusions of the ventral plasma membrane in a fibrobectin-dependent manner. Colocalizes with extracellular components (ECM), such as collagen fibers and fibronectin. .; [Antiplasmin-cleaving enzyme FAP, soluble form]: Secreted . Found in blood plasma and serum. .; [Isoform 2]: Cytoplasm .
組織表達(dá)： Expressed in adipose tissue. Expressed in the dermal fibroblasts in the fetal skin. Expressed in the granulation tissue of healing wounds and on reactive stromal fibroblast in epithelial cancers. Expressed in activated fibroblast-like synoviocytes from inflamed synovial tissues. Expressed in activated hepatic stellate cells (HSC) and myofibroblasts from cirrhotic liver, but not detected in normal liver. Expressed in glioma cells (at protein level). Expressed in glioblastomas and glioma cells. Isoform 1 and isoform 2 are expressed in melanoma, carcinoma and fibroblast cell lines.
科研貨號(hào)： PLA001050

Total Seprase Cell-Based Colorimetric ELISA Kit

Catalog No PLA001050

Product information

發(fā)貨日期： 14
基因名稱： FAP
Human_gene_id： 2191
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2191
Human_swiss_prot_no： Q12884
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q12884/entry
Mouse_swiss_prot_no： P97321
Mouse_swiss_link： http://www.uniprot.org/uniprot/P97321
儲(chǔ)存： 2-8°C/6 months
說(shuō)明書： KA3255C.pdf
其他名稱： Seprase (EC 3.4.21.-) (170 kDa melanoma membrane-bound gelatinase) (Fibroblast activation protein alpha) (Integral membrane serine protease)
功能： proteolysis,
相關(guān)產(chǎn)品： YT6136,YT4244,KA3255C,KE1372,KE1709
細(xì)胞定位： [Prolyl endopeptidase FAP]: Cell surface . Cell membrane ; Single-pass type II membrane protein . Cell projection, lamellipodium membrane ; Single-pass type II membrane protein . Cell projection, invadopodium membrane ; Single-pass type II membrane protein . Cell projection, ruffle membrane ; Single-pass type II membrane protein . Membrane ; Single-pass type II membrane protein . Localized on cell surface with lamellipodia and invadopodia membranes and on shed vesicles. Colocalized with DPP4 at invadopodia and lamellipodia membranes of migratory activated endothelial cells in collagenous matrix. Colocalized with DPP4 on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. Anchored and enriched preferentially by integrin alpha-3/beta-1 at invadopodia, plasma membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner. Colocalized with PLAUR preferentially at the cell surface of invadopodia membranes in a cytoskeleton-, integrin- and vitronectin-dependent manner. Concentrated at invadopodia membranes, specialized protrusions of the ventral plasma membrane in a fibrobectin-dependent manner. Colocalizes with extracellular components (ECM), such as collagen fibers and fibronectin. .; [Antiplasmin-cleaving enzyme FAP, soluble form]: Secreted . Found in blood plasma and serum. .; [Isoform 2]: Cytoplasm .
組織表達(dá)： Expressed in adipose tissue. Expressed in the dermal fibroblasts in the fetal skin. Expressed in the granulation tissue of healing wounds and on reactive stromal fibroblast in epithelial cancers. Expressed in activated fibroblast-like synoviocytes from inflamed synovial tissues. Expressed in activated hepatic stellate cells (HSC) and myofibroblasts from cirrhotic liver, but not detected in normal liver. Expressed in glioma cells (at protein level). Expressed in glioblastomas and glioma cells. Isoform 1 and isoform 2 are expressed in melanoma, carcinoma and fibroblast cell lines.
科研貨號(hào)： PLA001050

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