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Phospho Lamin A/C (S22) Cell-Based Colorimetric ELISA Kit

商品貨號： PLA000770

適應(yīng) 性： 人,小鼠,大鼠

￥2400元

規(guī)格：

96T

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MSDS

說明書

商品描述

發(fā)貨日期： 14
基因名稱： LMNA
Human_gene_id： 4000
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4000
Human_swiss_prot_no： P02545
Human_swiss_link： http://www.uniprot.org/uniprotkb/P02545/entry
Mouse_swiss_prot_no： P48678
Mouse_swiss_link： http://www.uniprot.org/uniprot/P48678
Rat_swiss_prot_no： P48679
Rat_swiss_link： http://www.uniprot.org/uniprot/O54941P48679
儲存： 2-8°C/6 months
說明書： KA1768C.pdf
其他名稱： Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
功能： nucleus organization,?nuclear envelope organization,?gamete generation,?spermatogenesis,?muscle organ development,?endomembrane organization,?membrane organization,?sexual reproduction,?multicellular organism reproduction,?male gamete generation,?reproductive process in a multicellular organism,
相關(guān)產(chǎn)品： YT2521,YT2520,YP0882,YP0485,YC0058,YC0057,KA4158C,KA3930C,KA3929C,KA1768C,KA1297C
細胞定位： Nucleus . Nucleus envelope . Nucleus lamina. Nucleus, nucleoplasm. Nucleus matrix . Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleavage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C.; [Isoform C]: Nucleus speckle .
組織表達： In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress.
科研貨號： PLA000770

Phospho Lamin A/C (S22) Cell-Based Colorimetric ELISA Kit

Catalog No PLA000770

Product information

發(fā)貨日期： 14
基因名稱： LMNA
Human_gene_id： 4000
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4000
Human_swiss_prot_no： P02545
Human_swiss_link： http://www.uniprot.org/uniprotkb/P02545/entry
Mouse_swiss_prot_no： P48678
Mouse_swiss_link： http://www.uniprot.org/uniprot/P48678
Rat_swiss_prot_no： P48679
Rat_swiss_link： http://www.uniprot.org/uniprot/O54941P48679
儲存： 2-8°C/6 months
說明書： KA1768C.pdf
其他名稱： Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
功能： nucleus organization,?nuclear envelope organization,?gamete generation,?spermatogenesis,?muscle organ development,?endomembrane organization,?membrane organization,?sexual reproduction,?multicellular organism reproduction,?male gamete generation,?reproductive process in a multicellular organism,
相關(guān)產(chǎn)品： YT2521,YT2520,YP0882,YP0485,YC0058,YC0057,KA4158C,KA3930C,KA3929C,KA1768C,KA1297C
細胞定位： Nucleus . Nucleus envelope . Nucleus lamina. Nucleus, nucleoplasm. Nucleus matrix . Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleavage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C.; [Isoform C]: Nucleus speckle .
組織表達： In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress.
科研貨號： PLA000770

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